STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tyk2Tyrosine-protein kinase. (1165 aa)    
Predicted Functional Partners:
stat1a
Signal transducer and activator of transcription.
   
 0.994
stat2
Signal transducer and activator of transcription.
   
 0.991
crfb4
Cytokine receptor family member b4.
   
 0.990
stat1b
Signal transducer and activator of transcription.
   
 0.980
socs3a
Suppressor of cytokine-signaling 3a.
   
 0.977
il10rb
Interleukin 10 receptor, beta.
   
 0.972
socs3b
Suppressor of cytokine-signaling 3b.
   
 0.959
stat3
Signal transducer and activator of transcription.
   
 0.958
jak1
Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures.
  
  
0.947
stat5a
Signal transducer and activator of transcription.
   
 0.942
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.