STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
renRenin; Belongs to the peptidase A1 family. (395 aa)    
Predicted Functional Partners:
ace2
Angiotensin-converting enzyme.
      
 0.977
agt
Angiotensinogen; Belongs to the serpin family.
   
 0.974
atp6ap2
ATPase H+-transporting accessory protein 2.
   
 0.972
ace
Angiotensin-converting enzyme.
      
 0.962
agtr1a
Angiotensin II receptor, type 1a; Belongs to the G-protein coupled receptor 1 family.
      
 0.728
edn1
Endothelin 1.
   
  
 0.679
apln
Apelin; Endogenous ligand for the apelin receptor (aplnra and/or aplnrb). Drives internalization of the apelin receptor (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis. Plays a role in early coronary blood vessels formation. Mediates myocardial contractility in an ERK1/2-dependent manner. May also have a role in the central control of body fluid homeostasis (By similarity).
      
 0.669
nr3c2
Nuclear receptor subfamily 3, group C, member 2.
    
 
 0.647
nphs2
NPHS2 stomatin family member, podocin.
   
 
 0.620
ins
Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
   
 
 0.606
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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