STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
xkrxXK-related protein. (475 aa)    
Predicted Functional Partners:
tbxas1
Thromboxane A synthase 1 (platelet); Belongs to the cytochrome P450 family.
   
 
 0.854
nek3
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
      
 0.835
ptprub
Receptor-type tyrosine-protein phosphatase U; Tyrosine-protein phosphatase which dephosphorylates CTNNB1. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. Functions in somitogenesis. Functions as a regulator of the biochemical clock responsible for the segmentation of the presomitic mesoderm; Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
   
  
 0.810
fam53b
Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (ctnnb1) nuclear localization. Required for appendage regeneration by regulating cell proliferation.
   
  
 0.693
smc4
Structural maintenance of chromosomes protein.
    
 
 0.687
lipca
Lipase, hepatic a.
   
  
 0.672
il23r
Interleukin 23 receptor.
   
  
 0.651
rap2c
RAP2C, member of RAS oncogene family.
   
 
 0.645
parla
Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of opa1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity); Belongs to the peptidase S54 family.
      
 0.611
duox2
Dual oxidase 2.
   
 
 0.593
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.