STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bace2Zgc:103530 protein; Belongs to the peptidase A1 family. (372 aa)    
Predicted Functional Partners:
LOC100331987
Seizure-related 6 homolog (mouse)-like.
   
 
 0.880
gga1
Golgi-associated, gamma adaptin ear-containing, ARF-binding protein 1.
    
 
 0.820
sez6l2
Seizure-related 6 homolog (mouse)-like 2.
   
 
 0.809
appa
Amyloid beta (A4) precursor protein a.
    
 
 0.797
psenen
Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins.
   
  
 0.699
tmem200a
Transmembrane protein 200A.
      
 0.654
aplp2
Amyloid beta (A4) precursor-like protein 2.
    
 
 0.620
psen1
Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family.
   
 
 0.620
adam17b
ADAM metallopeptidase domain 17b.
   
 
 0.616
pmela
Premelanosome protein a.
   
  
 0.597
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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