node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cdc45 | cdc6 | ENSDARP00000064200 | ENSDARP00000008736 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.994 |
cdc45 | cdc7 | ENSDARP00000064200 | ENSDARP00000091380 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. | 0.984 |
cdc45 | cdt1 | ENSDARP00000064200 | ENSDARP00000089247 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | Chromatin licensing and DNA replication factor 1. | 0.995 |
cdc45 | mcm10 | ENSDARP00000064200 | ENSDARP00000067338 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | Protein MCM10 homolog; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity). | 0.999 |
cdc45 | mcm2 | ENSDARP00000064200 | ENSDARP00000133012 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | DNA helicase; Belongs to the MCM family. | 0.999 |
cdc45 | mcm3 | ENSDARP00000064200 | ENSDARP00000003671 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | DNA helicase; Belongs to the MCM family. | 0.998 |
cdc45 | mcm4 | ENSDARP00000064200 | ENSDARP00000058563 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | DNA helicase; Belongs to the MCM family. | 0.999 |
cdc45 | mcm5 | ENSDARP00000064200 | ENSDARP00000018877 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | DNA helicase; Belongs to the MCM family. | 0.999 |
cdc45 | mcm6 | ENSDARP00000064200 | ENSDARP00000022256 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | DNA helicase; Belongs to the MCM family. | 0.999 |
cdc45 | mcm7 | ENSDARP00000064200 | ENSDARP00000132487 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
cdc6 | cdc45 | ENSDARP00000008736 | ENSDARP00000064200 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | CDC45 cell division cycle 45 homolog (S. cerevisiae). | 0.994 |
cdc6 | cdc7 | ENSDARP00000008736 | ENSDARP00000091380 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. | 0.973 |
cdc6 | cdt1 | ENSDARP00000008736 | ENSDARP00000089247 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Chromatin licensing and DNA replication factor 1. | 0.999 |
cdc6 | mcm10 | ENSDARP00000008736 | ENSDARP00000067338 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Protein MCM10 homolog; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity). | 0.996 |
cdc6 | mcm2 | ENSDARP00000008736 | ENSDARP00000133012 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.999 |
cdc6 | mcm3 | ENSDARP00000008736 | ENSDARP00000003671 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.996 |
cdc6 | mcm4 | ENSDARP00000008736 | ENSDARP00000058563 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.999 |
cdc6 | mcm5 | ENSDARP00000008736 | ENSDARP00000018877 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.999 |
cdc6 | mcm6 | ENSDARP00000008736 | ENSDARP00000022256 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.996 |
cdc6 | mcm7 | ENSDARP00000008736 | ENSDARP00000132487 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |