node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acaca | acadm | ENSDARP00000077514 | ENSDARP00000117024 | Acetyl-CoA carboxylase alpha. | Acyl-CoA dehydrogenase medium chain. | 0.674 |
acaca | acat1 | ENSDARP00000077514 | ENSDARP00000133230 | Acetyl-CoA carboxylase alpha. | Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...] | 0.973 |
acaca | eci2 | ENSDARP00000077514 | ENSDARP00000130260 | Acetyl-CoA carboxylase alpha. | Enoyl-CoA delta isomerase 2. | 0.639 |
acaca | ehhadh | ENSDARP00000077514 | ENSDARP00000093211 | Acetyl-CoA carboxylase alpha. | Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.499 |
acaca | hadh | ENSDARP00000077514 | ENSDARP00000050602 | Acetyl-CoA carboxylase alpha. | Hydroxyacyl-Coenzyme A dehydrogenase. | 0.504 |
acaca | hadhaa | ENSDARP00000077514 | ENSDARP00000074186 | Acetyl-CoA carboxylase alpha. | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.533 |
acaca | hadhab | ENSDARP00000077514 | ENSDARP00000070488 | Acetyl-CoA carboxylase alpha. | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.528 |
acaca | hmgcl | ENSDARP00000077514 | ENSDARP00000026028 | Acetyl-CoA carboxylase alpha. | 3-hydroxy-3-methylglutaryl-CoA lyase. | 0.461 |
acaca | hmgcs1 | ENSDARP00000077514 | ENSDARP00000137373 | Acetyl-CoA carboxylase alpha. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.554 |
acadm | acaca | ENSDARP00000117024 | ENSDARP00000077514 | Acyl-CoA dehydrogenase medium chain. | Acetyl-CoA carboxylase alpha. | 0.674 |
acadm | acat1 | ENSDARP00000117024 | ENSDARP00000133230 | Acyl-CoA dehydrogenase medium chain. | Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...] | 0.976 |
acadm | eci2 | ENSDARP00000117024 | ENSDARP00000130260 | Acyl-CoA dehydrogenase medium chain. | Enoyl-CoA delta isomerase 2. | 0.921 |
acadm | ehhadh | ENSDARP00000117024 | ENSDARP00000093211 | Acyl-CoA dehydrogenase medium chain. | Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.978 |
acadm | hadh | ENSDARP00000117024 | ENSDARP00000050602 | Acyl-CoA dehydrogenase medium chain. | Hydroxyacyl-Coenzyme A dehydrogenase. | 0.938 |
acadm | hadhaa | ENSDARP00000117024 | ENSDARP00000074186 | Acyl-CoA dehydrogenase medium chain. | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.989 |
acadm | hadhab | ENSDARP00000117024 | ENSDARP00000070488 | Acyl-CoA dehydrogenase medium chain. | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.984 |
acadm | hmgcl | ENSDARP00000117024 | ENSDARP00000026028 | Acyl-CoA dehydrogenase medium chain. | 3-hydroxy-3-methylglutaryl-CoA lyase. | 0.585 |
acadm | hmgcs1 | ENSDARP00000117024 | ENSDARP00000137373 | Acyl-CoA dehydrogenase medium chain. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.494 |
acadm | oxct1a | ENSDARP00000117024 | ENSDARP00000002234 | Acyl-CoA dehydrogenase medium chain. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.469 |
acat1 | acaca | ENSDARP00000133230 | ENSDARP00000077514 | Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...] | Acetyl-CoA carboxylase alpha. | 0.973 |