STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nsmafNeutral sphingomyelinase (N-SMase) activation-associated factor. (911 aa)    
Predicted Functional Partners:
tnfrsf1a
Tumor necrosis factor receptor superfamily, member 1a.
    
 0.839
smpd2a
Sphingomyelin phosphodiesterase 2a.
      
 0.759
smpd3
Sphingomyelin phosphodiesterase 3.
     
 0.685
smpd2b
Sphingomyelin phosphodiesterase 2b.
     
 0.657
rack1
Guanine nucleotide-binding protein subunit beta-2-like 1; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
    
0.649
psmb3
Proteasome subunit beta.
    
 
 0.601
smpd4
Sphingomyelin phosphodiesterase 4; Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide.
   
  
 0.601
psma1
Proteasome subunit alpha type.
    
 
 0.595
psmc3
Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.
      
 0.585
psmc1a
Proteasome (Prosome, macropain) 26S subunit, ATPase, 1a; Belongs to the AAA ATPase family.
   
 
 0.575
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.