node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
angpt2b | fgfr1a | ENSDARP00000070502 | ENSDARP00000013742 | Angiopoietin 2b. | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | 0.804 |
angpt2b | fgfr2 | ENSDARP00000070502 | ENSDARP00000124472 | Angiopoietin 2b. | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] | 0.764 |
angpt2b | flt1 | ENSDARP00000070502 | ENSDARP00000002466 | Angiopoietin 2b. | Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.919 |
angpt2b | flt4 | ENSDARP00000070502 | ENSDARP00000133227 | Angiopoietin 2b. | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | 0.911 |
angpt2b | kdr | ENSDARP00000070502 | ENSDARP00000049203 | Angiopoietin 2b. | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.947 |
angpt2b | kdrl | ENSDARP00000070502 | ENSDARP00000134625 | Angiopoietin 2b. | Vascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.946 |
angpt2b | pdgfba | ENSDARP00000070502 | ENSDARP00000146148 | Angiopoietin 2b. | Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. | 0.810 |
angpt2b | pdgfrb | ENSDARP00000070502 | ENSDARP00000152459 | Angiopoietin 2b. | Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.780 |
angpt2b | tek | ENSDARP00000070502 | ENSDARP00000055680 | Angiopoietin 2b. | Tyrosine-protein kinase receptor Tie-2; Tyrosine-protein kinase that acts as cell-surface receptor for angiopoietins and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Can activate or inhibit angiogenesis, depending on the context. Angiopoietin signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors (By similarity). | 0.999 |
angpt2b | tie1 | ENSDARP00000070502 | ENSDARP00000147239 | Angiopoietin 2b. | Tyrosine-protein kinase receptor Tie-1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. | 0.914 |
fgfr1a | angpt2b | ENSDARP00000013742 | ENSDARP00000070502 | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | Angiopoietin 2b. | 0.804 |
fgfr1a | fgfr2 | ENSDARP00000013742 | ENSDARP00000124472 | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] | 0.431 |
fgfr1a | pdgfba | ENSDARP00000013742 | ENSDARP00000146148 | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. | 0.811 |
fgfr2 | angpt2b | ENSDARP00000124472 | ENSDARP00000070502 | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] | Angiopoietin 2b. | 0.764 |
fgfr2 | fgfr1a | ENSDARP00000124472 | ENSDARP00000013742 | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | 0.431 |
fgfr2 | pdgfba | ENSDARP00000124472 | ENSDARP00000146148 | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] | Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. | 0.773 |
flt1 | angpt2b | ENSDARP00000002466 | ENSDARP00000070502 | Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Angiopoietin 2b. | 0.919 |
flt1 | kdrl | ENSDARP00000002466 | ENSDARP00000134625 | Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Vascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.471 |
flt1 | pdgfba | ENSDARP00000002466 | ENSDARP00000146148 | Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. | 0.913 |
flt1 | pdgfrb | ENSDARP00000002466 | ENSDARP00000152459 | Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.425 |