node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acyp2 | tpmt.1 | ENSDARP00000104873 | ENSDARP00000072844 | Acylphosphatase. | Probable thiopurine S-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | 0.804 |
cyp2x6 | mtfr1 | ENSDARP00000064590 | ENSDARP00000066627 | Cytochrome P450, family 2, subfamily X, polypeptide 6; Belongs to the cytochrome P450 family. | Mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). | 0.898 |
cyp2x6 | tpmt.1 | ENSDARP00000064590 | ENSDARP00000072844 | Cytochrome P450, family 2, subfamily X, polypeptide 6; Belongs to the cytochrome P450 family. | Probable thiopurine S-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | 0.837 |
gmps | hprt1l | ENSDARP00000097707 | ENSDARP00000008019 | Guanine monophosphate synthase. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.948 |
gmps | impdh1a | ENSDARP00000097707 | ENSDARP00000019185 | Guanine monophosphate synthase. | Inosine-5'-monophosphate dehydrogenase 1a; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.994 |
gmps | impdh1b | ENSDARP00000097707 | ENSDARP00000066974 | Guanine monophosphate synthase. | Inosine-5'-monophosphate dehydrogenase 1b; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.994 |
gmps | impdh2 | ENSDARP00000097707 | ENSDARP00000024354 | Guanine monophosphate synthase. | Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.994 |
gmps | itpa | ENSDARP00000097707 | ENSDARP00000074674 | Guanine monophosphate synthase. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.969 |
gmps | tpmt.1 | ENSDARP00000097707 | ENSDARP00000072844 | Guanine monophosphate synthase. | Probable thiopurine S-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | 0.916 |
hprt1l | gmps | ENSDARP00000008019 | ENSDARP00000097707 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanine monophosphate synthase. | 0.948 |
hprt1l | impdh1a | ENSDARP00000008019 | ENSDARP00000019185 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase 1a; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.963 |
hprt1l | impdh1b | ENSDARP00000008019 | ENSDARP00000066974 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase 1b; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.958 |
hprt1l | impdh2 | ENSDARP00000008019 | ENSDARP00000024354 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.932 |
hprt1l | itpa | ENSDARP00000008019 | ENSDARP00000074674 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.922 |
hprt1l | tpmt.1 | ENSDARP00000008019 | ENSDARP00000072844 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Probable thiopurine S-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. | 0.909 |
hprt1l | xdh | ENSDARP00000008019 | ENSDARP00000072020 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Xanthine dehydrogenase. | 0.902 |
impdh1a | gmps | ENSDARP00000019185 | ENSDARP00000097707 | Inosine-5'-monophosphate dehydrogenase 1a; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Guanine monophosphate synthase. | 0.994 |
impdh1a | hprt1l | ENSDARP00000019185 | ENSDARP00000008019 | Inosine-5'-monophosphate dehydrogenase 1a; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.963 |
impdh1a | impdh1b | ENSDARP00000019185 | ENSDARP00000066974 | Inosine-5'-monophosphate dehydrogenase 1a; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Inosine-5'-monophosphate dehydrogenase 1b; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.901 |
impdh1a | impdh2 | ENSDARP00000019185 | ENSDARP00000024354 | Inosine-5'-monophosphate dehydrogenase 1a; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.900 |