STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dixdc1aDixin-A; Functions as a positive effector of the Wnt signaling pathway regulating antero-posterior neural patterning. (443 aa)    
Predicted Functional Partners:
disc1
DISC1 scaffold protein.
    
 
 0.711
nde1
NudE neurodevelopment protein 1.
    
 
 0.658
axin2
Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos.
   
 
 0.598
ccdc88c
Protein Daple; Positive regulator of Wnt signaling, acting synergistically with dvl2 (By similarity). Functions upstream of ctnnb1/beta-catenin in the canonical Wnt pathway, and also activates jnk in the Wnt/planar cell polarity (PCP) pathway (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits. This promotes apical cell constriction and subsequent bending of the neural plate during neurulation via arhgef18 (By similarity).
   
  
 0.585
cdk12
Cyclin-dependent kinase 12.
    
 
 0.582
cdk13
Cyclin-dependent kinase 13.
    
 
 0.582
ccdc88b
Coiled-coil domain-containing 88B.
      
 0.556
ccnt1
Cyclin T1; Belongs to the cyclin family.
   
 
 0.455
ccnt2b
Zgc:55690 protein; Belongs to the cyclin family.
   
 
 0.455
ccnt2a
Cyclin T2a; Belongs to the cyclin family.
   
 
 0.455
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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