STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tmub2Transmembrane and ubiquitin-like domain-containing 2. (291 aa)    
Predicted Functional Partners:
ubxn1
UBX domain-containing protein 1; Ubiquitin-binding protein that specifically binds 'Lys-6'- linked polyubiquitin chains. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems (By similarity).
      
 0.582
man1a2
alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.
      
 0.567
pip5k1aa
Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a.
   
  
 0.564
uba5
Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates ufm1 and sumo2.
      
 0.552
ufc1
Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with ufm1 via a thioester linkage.
   
 
 0.549
stt3b
STT3 oligosaccharyltransferase complex catalytic subunit B.
   
  
 0.544
sec61a1
Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development.
      
 0.540
stt3a
STT3 oligosaccharyltransferase complex catalytic subunit A.
      
 0.540
derl2
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
   
  
 0.491
nedd8
NEDD8 ubiquitin-like modifier.
   
 
 0.461
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (30%) [HD]