node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
derl2 | man1a2 | ENSDARP00000062174 | ENSDARP00000143611 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. | 0.464 |
derl2 | sec61a1 | ENSDARP00000062174 | ENSDARP00000033318 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development. | 0.527 |
derl2 | tmub2 | ENSDARP00000062174 | ENSDARP00000073431 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | Transmembrane and ubiquitin-like domain-containing 2. | 0.491 |
derl2 | ubxn1 | ENSDARP00000062174 | ENSDARP00000108064 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | UBX domain-containing protein 1; Ubiquitin-binding protein that specifically binds 'Lys-6'- linked polyubiquitin chains. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems (By similarity). | 0.815 |
man1a2 | derl2 | ENSDARP00000143611 | ENSDARP00000062174 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | 0.464 |
man1a2 | tmub2 | ENSDARP00000143611 | ENSDARP00000073431 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. | Transmembrane and ubiquitin-like domain-containing 2. | 0.567 |
man1a2 | ubxn1 | ENSDARP00000143611 | ENSDARP00000108064 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. | UBX domain-containing protein 1; Ubiquitin-binding protein that specifically binds 'Lys-6'- linked polyubiquitin chains. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems (By similarity). | 0.567 |
nedd8 | tmub2 | ENSDARP00000021095 | ENSDARP00000073431 | NEDD8 ubiquitin-like modifier. | Transmembrane and ubiquitin-like domain-containing 2. | 0.461 |
nedd8 | uba5 | ENSDARP00000021095 | ENSDARP00000087478 | NEDD8 ubiquitin-like modifier. | Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates ufm1 and sumo2. | 0.719 |
nedd8 | ufc1 | ENSDARP00000021095 | ENSDARP00000036899 | NEDD8 ubiquitin-like modifier. | Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with ufm1 via a thioester linkage. | 0.520 |
pip5k1aa | tmub2 | ENSDARP00000130044 | ENSDARP00000073431 | Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a. | Transmembrane and ubiquitin-like domain-containing 2. | 0.564 |
sec61a1 | derl2 | ENSDARP00000033318 | ENSDARP00000062174 | Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development. | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | 0.527 |
sec61a1 | stt3a | ENSDARP00000033318 | ENSDARP00000136997 | Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development. | STT3 oligosaccharyltransferase complex catalytic subunit A. | 0.952 |
sec61a1 | stt3b | ENSDARP00000033318 | ENSDARP00000093301 | Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development. | STT3 oligosaccharyltransferase complex catalytic subunit B. | 0.951 |
sec61a1 | tmub2 | ENSDARP00000033318 | ENSDARP00000073431 | Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development. | Transmembrane and ubiquitin-like domain-containing 2. | 0.540 |
sec61a1 | uba5 | ENSDARP00000033318 | ENSDARP00000087478 | Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development. | Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates ufm1 and sumo2. | 0.508 |
sec61a1 | ufc1 | ENSDARP00000033318 | ENSDARP00000036899 | Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development. | Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with ufm1 via a thioester linkage. | 0.433 |
stt3a | sec61a1 | ENSDARP00000136997 | ENSDARP00000033318 | STT3 oligosaccharyltransferase complex catalytic subunit A. | Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development. | 0.952 |
stt3a | stt3b | ENSDARP00000136997 | ENSDARP00000093301 | STT3 oligosaccharyltransferase complex catalytic subunit A. | STT3 oligosaccharyltransferase complex catalytic subunit B. | 0.962 |
stt3a | tmub2 | ENSDARP00000136997 | ENSDARP00000073431 | STT3 oligosaccharyltransferase complex catalytic subunit A. | Transmembrane and ubiquitin-like domain-containing 2. | 0.540 |