STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cpvlCarboxypeptidase, vitellogenic-like; Belongs to the peptidase S10 family. (478 aa)    
Predicted Functional Partners:
stk17a
Serine/threonine kinase 17a; Belongs to the protein kinase superfamily.
      
 0.830
mfsd6a
Major facilitator superfamily domain-containing protein 6-A.
      
 0.760
zgc:162879
Ras and EF-hand domain-containing protein; Binds predominantly GDP, and also GTP.
      
 0.754
rasef
Ras and EF-hand domain-containing protein.
      
 0.754
arpc5b
Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
   
  
 0.680
tmtc2a
Transmembrane O-mannosyltransferase targeting cadherins 2a.
    
 
 0.665
akr1b1.1
Aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 1.
   
  
 0.653
UNC13B
Unc-13 homolog B.
      
 0.644
espl1
Extra spindle pole bodies-like 1, separase.
      
 0.599
zgc:91968
Melanoregulin; Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinosi [...]
      
 0.598
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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