STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cmasaN-acylneuraminate cytidylyltransferase A; Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Also has activity towards N-glycolylneuraminic acid (Neu5Gc). Has weak activity towards 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN) (430 aa)    
Predicted Functional Partners:
nans
N-acetylneuraminic acid synthase
 
 0.980
nanp
N-acetylneuraminic acid phosphatase
  
 
 0.944
cmah
Cytidine monophosphate-N-acetylneuraminic acid hydroxylase; Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N- acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells
     
 0.929
ppa1b
Pyrophosphatase (inorganic) 1b
   
  
 0.832
cmas2
N-acylneuraminate cytidylyltransferase B; Catalyzes the activation of 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN) to cytidine 5'-monophosphate 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (CMP-KDN), a substrate required for the addition of sialic acid. Also has weak activity towards N-acetylneuraminic acid (NeuNAc) and N-glycolylneuraminic acid (Neu5Gc); Belongs to the CMP-NeuNAc synthase family
  
  
0.812
zgc:101549
N-acetylneuraminic acid synthase
  
 0.806
npl
N-acetylneuraminate lyase; Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity)
  
  
 0.657
st8sia3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3; Belongs to the glycosyltransferase 29 family
   
 
 0.640
ft2
Alpha(1,3)fucosyltransferase gene 2
      
 0.600
slc35a1
Solute carrier family 35 (CMP-sialic acid transporter), member A1
   
  
 0.597
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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