node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apc2 | cdh1 | ENSDARP00000086097 | ENSDARP00000136579 | APC regulator of WNT-signaling pathway 2. | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | 0.569 |
apc2 | cdh5 | ENSDARP00000086097 | ENSDARP00000104309 | APC regulator of WNT-signaling pathway 2. | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | 0.548 |
apc2 | ctnna1 | ENSDARP00000086097 | ENSDARP00000132933 | APC regulator of WNT-signaling pathway 2. | Catenin (cadherin-associated protein), alpha 1. | 0.720 |
apc2 | ctnna2 | ENSDARP00000086097 | ENSDARP00000092080 | APC regulator of WNT-signaling pathway 2. | Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system; Belongs to the vinculin/alpha-catenin family. | 0.723 |
apc2 | ctnnb1 | ENSDARP00000086097 | ENSDARP00000139205 | APC regulator of WNT-signaling pathway 2. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.981 |
apc2 | ctnnb2 | ENSDARP00000086097 | ENSDARP00000076115 | APC regulator of WNT-signaling pathway 2. | Catenin, beta 2. | 0.977 |
apc2 | jupb | ENSDARP00000086097 | ENSDARP00000076517 | APC regulator of WNT-signaling pathway 2. | Junction plakoglobin b. | 0.840 |
ccdc130 | ctnnb1 | ENSDARP00000060887 | ENSDARP00000139205 | Coiled-coil domain-containing protein 130 homolog; Belongs to the CWC16 family. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.589 |
ccdc130 | ctnnb2 | ENSDARP00000060887 | ENSDARP00000076115 | Coiled-coil domain-containing protein 130 homolog; Belongs to the CWC16 family. | Catenin, beta 2. | 0.601 |
ccdc130 | jupb | ENSDARP00000060887 | ENSDARP00000076517 | Coiled-coil domain-containing protein 130 homolog; Belongs to the CWC16 family. | Junction plakoglobin b. | 0.857 |
cdh1 | apc2 | ENSDARP00000136579 | ENSDARP00000086097 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | APC regulator of WNT-signaling pathway 2. | 0.569 |
cdh1 | cdh5 | ENSDARP00000136579 | ENSDARP00000104309 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | 0.693 |
cdh1 | ctnna1 | ENSDARP00000136579 | ENSDARP00000132933 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Catenin (cadherin-associated protein), alpha 1. | 0.859 |
cdh1 | ctnna2 | ENSDARP00000136579 | ENSDARP00000092080 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system; Belongs to the vinculin/alpha-catenin family. | 0.775 |
cdh1 | ctnnb1 | ENSDARP00000136579 | ENSDARP00000139205 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.999 |
cdh1 | ctnnb2 | ENSDARP00000136579 | ENSDARP00000076115 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Catenin, beta 2. | 0.953 |
cdh1 | jupb | ENSDARP00000136579 | ENSDARP00000076517 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Junction plakoglobin b. | 0.799 |
cdh1 | wu:fi04e12 | ENSDARP00000136579 | ENSDARP00000103914 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Wu:fi04e12. | 0.667 |
cdh5 | apc2 | ENSDARP00000104309 | ENSDARP00000086097 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | APC regulator of WNT-signaling pathway 2. | 0.548 |
cdh5 | cdh1 | ENSDARP00000104309 | ENSDARP00000136579 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | 0.693 |