node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TMEM216 | ZNF423 | ENSDARP00000111752 | ENSDARP00000156375 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons (By similarity); Belongs to the kr [...] | 0.570 |
TMEM216 | ahi1 | ENSDARP00000111752 | ENSDARP00000124018 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | Abelson helper integration site 1. | 0.982 |
TMEM216 | cep290 | ENSDARP00000111752 | ENSDARP00000124972 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] | 0.959 |
TMEM216 | nek8 | ENSDARP00000111752 | ENSDARP00000067094 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. | 0.671 |
TMEM216 | nphp1 | ENSDARP00000111752 | ENSDARP00000063715 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | Nephronophthisis 1. | 0.942 |
TMEM216 | ofd1 | ENSDARP00000111752 | ENSDARP00000000952 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | Oral-facial-digital syndrome 1 protein homolog; Component of the centrioles controlling mother and daughter centrioles length. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis; Belongs to the OFD1 family. | 0.855 |
TMEM216 | rpgrip1l | ENSDARP00000111752 | ENSDARP00000107198 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | RPGRIP1-like. | 0.930 |
TMEM216 | tmem231 | ENSDARP00000111752 | ENSDARP00000061995 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). | 0.984 |
TMEM216 | tmem67 | ENSDARP00000111752 | ENSDARP00000116688 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | Transmembrane protein 67. | 0.998 |
TMEM216 | ttc21b | ENSDARP00000111752 | ENSDARP00000044269 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | Tetratricopeptide repeat domain 21B. | 0.747 |
ZNF423 | TMEM216 | ENSDARP00000156375 | ENSDARP00000111752 | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons (By similarity); Belongs to the kr [...] | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | 0.570 |
ZNF423 | ahi1 | ENSDARP00000156375 | ENSDARP00000124018 | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons (By similarity); Belongs to the kr [...] | Abelson helper integration site 1. | 0.587 |
ZNF423 | cep290 | ENSDARP00000156375 | ENSDARP00000124972 | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons (By similarity); Belongs to the kr [...] | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] | 0.584 |
ZNF423 | nek8 | ENSDARP00000156375 | ENSDARP00000067094 | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons (By similarity); Belongs to the kr [...] | Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. | 0.746 |
ZNF423 | nphp1 | ENSDARP00000156375 | ENSDARP00000063715 | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons (By similarity); Belongs to the kr [...] | Nephronophthisis 1. | 0.663 |
ZNF423 | ofd1 | ENSDARP00000156375 | ENSDARP00000000952 | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons (By similarity); Belongs to the kr [...] | Oral-facial-digital syndrome 1 protein homolog; Component of the centrioles controlling mother and daughter centrioles length. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis; Belongs to the OFD1 family. | 0.573 |
ZNF423 | rpgrip1l | ENSDARP00000156375 | ENSDARP00000107198 | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons (By similarity); Belongs to the kr [...] | RPGRIP1-like. | 0.632 |
ZNF423 | tmem231 | ENSDARP00000156375 | ENSDARP00000061995 | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons (By similarity); Belongs to the kr [...] | Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). | 0.567 |
ZNF423 | tmem67 | ENSDARP00000156375 | ENSDARP00000116688 | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons (By similarity); Belongs to the kr [...] | Transmembrane protein 67. | 0.568 |
ZNF423 | ttc21b | ENSDARP00000156375 | ENSDARP00000044269 | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons (By similarity); Belongs to the kr [...] | Tetratricopeptide repeat domain 21B. | 0.559 |