STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sin3aaSIN3 transcription regulator family member Aa. (1276 aa)    
Predicted Functional Partners:
hdac1
Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
   
 
 0.995
sinhcaf
Family with sequence similarity 60, member A.
   
 0.949
sap30l
Histone deacetylase complex subunit SAP30L; Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Required for normal expression of numerous target genes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double- stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3- phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding a [...]
    
 
 0.946
suds3
Suppressor of defective silencing 3 homolog (SDS3, S. cerevisiae).
   
 0.942
brms1
BRMS1 transcriptional repressor and anoikis regulator.
   
 0.937
arid4a
AT-rich interactive domain 4A (RBP1-like).
   
 
 0.935
arid4b
Translocase of outer mitochondrial membrane 20.
   
 
 0.933
ncor1
Nuclear receptor corepressor 1.
   
 
 0.929
rcor1
REST corepressor 1.
   
  
 0.918
sap18
Histone deacetylase complex subunit SAP18; Involved in the tethering of the SIN3 complex to core histone proteins.
    
 
 0.911
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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