STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
shank1SH3 and multiple ankyrin repeat domains 1. (852 aa)    
Predicted Functional Partners:
dlg4
Disks large homolog 4; Plays a role in synapse assembly and function. Plays a role in synaptic plasticity.
   
 
 0.781
naa30
N(alpha)-acetyltransferase 30, NatC catalytic subunit.
    
 
 0.695
dlgap3
Discs, large (Drosophila) homolog-associated protein 3.
   
 
 0.673
dlgap1a
Disks large-associated protein 1; Part of the postsynaptic scaffold in neuronal cells. Belongs to the SAPAP family.
   
 
 0.658
fam171a1
Family with sequence similarity 171 member A1.
      
 0.648
neurl1b
Neuralized E3 ubiquitin protein ligase 1B.
    
 
 0.638
cntnap2a
Contactin-associated protein 2a.
    
 
 0.597
mecp2
Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
      
 0.590
homer1b
Homer scaffold protein 1b.
    
 
 0.586
im:7152348
Im:7152348.
   
 
 0.573
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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