STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
plekho1aPleckstrin homology domain-containing family O member 1-A; Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). (520 aa)    
Predicted Functional Partners:
dock5
Dedicator of cytokinesis 5; Belongs to the DOCK family.
      
 0.702
arpc4l
Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.
      
 0.645
arpc4
Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.
      
 0.645
cdh15
Cadherin 15, type 1, M-cadherin (myotubule); Cadherins are calcium-dependent cell adhesion proteins.
      
 0.556
spopla
Speckle-type POZ protein-like A; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency; Belongs to the Tdpoz family.
      
 0.551
smurf1
E3 ubiquitin-protein ligase.
      
 0.543
aox6
Aldehyde oxidase beta.
   
  
 0.480
cdc42l2
Cell division cycle 42-like 2.
      
 0.474
vaspa
Vasodilator-stimulated phosphoprotein a.
      
 0.473
fbxo11b
F-box protein 11a.
      
 0.438
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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