node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
arhgef12b | tgfbrap1 | ENSDARP00000139791 | ENSDARP00000082230 | Rho guanine nucleotide exchange factor (GEF) 12b. | Transforming growth factor-beta receptor-associated protein 1 homolog; Plays a role in the TGF-beta signaling pathway. Belongs to the TRAP1 family. | 0.835 |
ccz1 | tgfbrap1 | ENSDARP00000073520 | ENSDARP00000082230 | Vacuolar fusion protein CCZ1 homolog. | Transforming growth factor-beta receptor-associated protein 1 homolog; Plays a role in the TGF-beta signaling pathway. Belongs to the TRAP1 family. | 0.789 |
ccz1 | vps11 | ENSDARP00000073520 | ENSDARP00000052786 | Vacuolar fusion protein CCZ1 homolog. | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. | 0.990 |
ccz1 | vps16 | ENSDARP00000073520 | ENSDARP00000078255 | Vacuolar fusion protein CCZ1 homolog. | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. | 0.984 |
ccz1 | vps18 | ENSDARP00000073520 | ENSDARP00000094129 | Vacuolar fusion protein CCZ1 homolog. | Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). May be involved in vesicle trafficking to the hepatocyte apical membrane and p [...] | 0.988 |
ccz1 | vps33a | ENSDARP00000073520 | ENSDARP00000133149 | Vacuolar fusion protein CCZ1 homolog. | VPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family. | 0.963 |
ccz1 | vps33b | ENSDARP00000073520 | ENSDARP00000065867 | Vacuolar fusion protein CCZ1 homolog. | Vacuolar protein sorting-associated protein 33B; May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating vipas39. In epithelial cells, the vps33b:vipas39 complex may play a role in the apical recycling pathway and in the maintenance of the apical- basolateral polarity (By similarity). Plays a role in bile duct development. ECO:0000250|UniProtKB:Q9H267, ; Belongs to the STXBP/unc-18/SEC1 [...] | 0.948 |
ccz1 | vps39 | ENSDARP00000073520 | ENSDARP00000100792 | Vacuolar fusion protein CCZ1 homolog. | VPS39 subunit of HOPS complex. | 0.993 |
ccz1 | vps41 | ENSDARP00000073520 | ENSDARP00000116849 | Vacuolar fusion protein CCZ1 homolog. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. | 0.972 |
ccz1 | vps8 | ENSDARP00000073520 | ENSDARP00000117166 | Vacuolar fusion protein CCZ1 homolog. | VPS8 subunit of CORVET complex. | 0.767 |
tgfbrap1 | arhgef12b | ENSDARP00000082230 | ENSDARP00000139791 | Transforming growth factor-beta receptor-associated protein 1 homolog; Plays a role in the TGF-beta signaling pathway. Belongs to the TRAP1 family. | Rho guanine nucleotide exchange factor (GEF) 12b. | 0.835 |
tgfbrap1 | ccz1 | ENSDARP00000082230 | ENSDARP00000073520 | Transforming growth factor-beta receptor-associated protein 1 homolog; Plays a role in the TGF-beta signaling pathway. Belongs to the TRAP1 family. | Vacuolar fusion protein CCZ1 homolog. | 0.789 |
tgfbrap1 | vps11 | ENSDARP00000082230 | ENSDARP00000052786 | Transforming growth factor-beta receptor-associated protein 1 homolog; Plays a role in the TGF-beta signaling pathway. Belongs to the TRAP1 family. | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. | 0.967 |
tgfbrap1 | vps16 | ENSDARP00000082230 | ENSDARP00000078255 | Transforming growth factor-beta receptor-associated protein 1 homolog; Plays a role in the TGF-beta signaling pathway. Belongs to the TRAP1 family. | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. | 0.970 |
tgfbrap1 | vps18 | ENSDARP00000082230 | ENSDARP00000094129 | Transforming growth factor-beta receptor-associated protein 1 homolog; Plays a role in the TGF-beta signaling pathway. Belongs to the TRAP1 family. | Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). May be involved in vesicle trafficking to the hepatocyte apical membrane and p [...] | 0.938 |
tgfbrap1 | vps33a | ENSDARP00000082230 | ENSDARP00000133149 | Transforming growth factor-beta receptor-associated protein 1 homolog; Plays a role in the TGF-beta signaling pathway. Belongs to the TRAP1 family. | VPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family. | 0.845 |
tgfbrap1 | vps33b | ENSDARP00000082230 | ENSDARP00000065867 | Transforming growth factor-beta receptor-associated protein 1 homolog; Plays a role in the TGF-beta signaling pathway. Belongs to the TRAP1 family. | Vacuolar protein sorting-associated protein 33B; May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating vipas39. In epithelial cells, the vps33b:vipas39 complex may play a role in the apical recycling pathway and in the maintenance of the apical- basolateral polarity (By similarity). Plays a role in bile duct development. ECO:0000250|UniProtKB:Q9H267, ; Belongs to the STXBP/unc-18/SEC1 [...] | 0.845 |
tgfbrap1 | vps39 | ENSDARP00000082230 | ENSDARP00000100792 | Transforming growth factor-beta receptor-associated protein 1 homolog; Plays a role in the TGF-beta signaling pathway. Belongs to the TRAP1 family. | VPS39 subunit of HOPS complex. | 0.927 |
tgfbrap1 | vps41 | ENSDARP00000082230 | ENSDARP00000116849 | Transforming growth factor-beta receptor-associated protein 1 homolog; Plays a role in the TGF-beta signaling pathway. Belongs to the TRAP1 family. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. | 0.921 |
tgfbrap1 | vps8 | ENSDARP00000082230 | ENSDARP00000117166 | Transforming growth factor-beta receptor-associated protein 1 homolog; Plays a role in the TGF-beta signaling pathway. Belongs to the TRAP1 family. | VPS8 subunit of CORVET complex. | 0.933 |