Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C4H12orf66 | bmt2 | ENSDARP00000117810 | ENSDARP00000084049 | KICSTOR complex protein C12orf66 homolog; As part of the KICSTOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. Belongs to the UPF0536 family. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.747 |
| C4H12orf66 | depdc5 | ENSDARP00000117810 | ENSDARP00000115238 | KICSTOR complex protein C12orf66 homolog; As part of the KICSTOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. Belongs to the UPF0536 family. | DEP domain-containing 5, GATOR1 subcomplex subunit. | 0.979 |
| C4H12orf66 | itfg2 | ENSDARP00000117810 | ENSDARP00000020383 | KICSTOR complex protein C12orf66 homolog; As part of the KICSTOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. Belongs to the UPF0536 family. | Integrin alpha FG-GAP repeat-containing 2. | 0.997 |
| C4H12orf66 | nprl2 | ENSDARP00000117810 | ENSDARP00000077473 | KICSTOR complex protein C12orf66 homolog; As part of the KICSTOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. Belongs to the UPF0536 family. | NPR2-like, GATOR1 complex subunit. | 0.975 |
| C4H12orf66 | nprl3 | ENSDARP00000117810 | ENSDARP00000039240 | KICSTOR complex protein C12orf66 homolog; As part of the KICSTOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. Belongs to the UPF0536 family. | NPR3-like, GATOR1 complex subunit. | 0.773 |
| C4H12orf66 | rhebl1 | ENSDARP00000117810 | ENSDARP00000057222 | KICSTOR complex protein C12orf66 homolog; As part of the KICSTOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. Belongs to the UPF0536 family. | Ras homolog, mTORC1-binding-like 1. | 0.437 |
| C4H12orf66 | rptor | ENSDARP00000117810 | ENSDARP00000132117 | KICSTOR complex protein C12orf66 homolog; As part of the KICSTOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. Belongs to the UPF0536 family. | Regulatory-associated protein of MTOR, complex 1. | 0.443 |
| bmt2 | C4H12orf66 | ENSDARP00000084049 | ENSDARP00000117810 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | KICSTOR complex protein C12orf66 homolog; As part of the KICSTOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. Belongs to the UPF0536 family. | 0.747 |
| bmt2 | depdc5 | ENSDARP00000084049 | ENSDARP00000115238 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | DEP domain-containing 5, GATOR1 subcomplex subunit. | 0.716 |
| bmt2 | flcn | ENSDARP00000084049 | ENSDARP00000084624 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Folliculin. | 0.666 |
| bmt2 | ier5 | ENSDARP00000084049 | ENSDARP00000004179 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Novel gene similar to human and rodent IER5 (Immediately early response 5). | 0.664 |
| bmt2 | itfg2 | ENSDARP00000084049 | ENSDARP00000020383 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Integrin alpha FG-GAP repeat-containing 2. | 0.798 |
| bmt2 | nprl2 | ENSDARP00000084049 | ENSDARP00000077473 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | NPR2-like, GATOR1 complex subunit. | 0.825 |
| bmt2 | nprl3 | ENSDARP00000084049 | ENSDARP00000039240 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | NPR3-like, GATOR1 complex subunit. | 0.694 |
| bmt2 | rhebl1 | ENSDARP00000084049 | ENSDARP00000057222 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Ras homolog, mTORC1-binding-like 1. | 0.667 |
| bmt2 | rptor | ENSDARP00000084049 | ENSDARP00000132117 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Regulatory-associated protein of MTOR, complex 1. | 0.665 |
| bmt2 | slc38a9 | ENSDARP00000084049 | ENSDARP00000041067 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Sodium-coupled neutral amino acid transporter 9; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of a [...] | 0.721 |
| depdc5 | C4H12orf66 | ENSDARP00000115238 | ENSDARP00000117810 | DEP domain-containing 5, GATOR1 subcomplex subunit. | KICSTOR complex protein C12orf66 homolog; As part of the KICSTOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. Belongs to the UPF0536 family. | 0.979 |
| depdc5 | bmt2 | ENSDARP00000115238 | ENSDARP00000084049 | DEP domain-containing 5, GATOR1 subcomplex subunit. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.716 |
| depdc5 | flcn | ENSDARP00000115238 | ENSDARP00000084624 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Folliculin. | 0.401 |
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