STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dennd11DENN domain-containing protein 11; Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form. (490 aa)    
Predicted Functional Partners:
dennd10
DENN domain-containing protein 10; Guanine nucleotide exchange factor (GEF) which may be involved in the regulation of late endocytic pathway homeostasis, including endosomal positioning, maturation and secretion. Belongs to the DENND10 family.
      
 0.597
avl9
AVL9 homolog (S. cerevisiase).
      
 0.597
RIC1
RIC1 homolog, RAB6A GEF complex partner 1.
      
 0.593
dennd6aa
DENN/MADD domain-containing 6Aa.
      
 0.592
rab30
RAB30, member RAS oncogene family.
      
 0.556
rab33ba
RAB33B, member RAS oncogene family a.
   
  
 0.536
stk16
Serine/threonine kinase 16.
   
  
 0.474
rnf103
Ring finger protein 103.
   
  
 0.418
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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