STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
stk24bSerine/threonine kinase 24b (STE20 homolog, yeast). (432 aa)    
Predicted Functional Partners:
strn
Striatin, calmodulin-binding protein.
    
 
 0.921
strip1
Striatin-interacting protein 1 homolog; May play a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (By similarity).
    
 
 0.914
tnikb
TRAF2 and NCK-interacting kinase b.
 
  
   0.902
pdcd10a
Programmed cell death protein 10-A; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development.
    
 
 0.877
strip2
Striatin-interacting protein 2.
   
 
 0.809
casp3a
Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.
     
  0.750
casp7
Caspase 7, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
     
  0.750
krit1
Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...]
   
  
 0.689
mob4
MOB1, Mps One Binder kinase activator-like 3 (Yeast).
   
 
 0.656
lrsam1
Leucine-rich repeat and sterile alpha motif-containing 1.
   
 
 0.648
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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