STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
smarcad1aDNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double- strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication (By similarity). (972 aa)    
Predicted Functional Partners:
exo1
Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity).
   
 
 0.802
hmg20a
High mobility group 20A.
   
  
 0.755
msh2
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
   
 
 0.723
smek1
Serine/threonine-protein phosphatase 4 regulatory subunit 3; Regulatory subunit of serine/threonine-protein phosphatase 4. Belongs to the SMEK family.
   
  
 0.703
xkr6b
XK-related protein.
      
 0.644
trim33
E3 ubiquitin-protein ligase TRIM33; May act as an E3 ubiquitin-protein ligase and a transcriptional repressor (By similarity). Involved in the regulation of embryonic and adult hematopoiesis. Required for normal development and survival of both committed erythroid progenitor cells and posterior mesenchymal cells.
   
 
 0.629
dna2
DNA replication helicase/nuclease 2.
    
 
 0.626
trim24
Tripartite motif-containing 24.
   
 
 0.618
smarcc1a
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily c, member 1a.
   
 
 0.596
trim33l
Tripartite motif-containing 33,-like.
   
 
 0.571
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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