node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
abca1a | abcg1 | ENSDARP00000132417 | ENSDARP00000087241 | ATP-binding cassette, sub-family A (ABC1), member 1A. | ATP-binding cassette, sub-family G (WHITE), member 1. | 0.496 |
abca1a | fasn | ENSDARP00000132417 | ENSDARP00000112100 | ATP-binding cassette, sub-family A (ABC1), member 1A. | Coiled-coil domain containing 57. | 0.619 |
abca1a | hmgcra | ENSDARP00000132417 | ENSDARP00000088231 | ATP-binding cassette, sub-family A (ABC1), member 1A. | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 0.604 |
abca1a | insig1 | ENSDARP00000132417 | ENSDARP00000018378 | ATP-binding cassette, sub-family A (ABC1), member 1A. | Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. | 0.457 |
abca1a | npc1 | ENSDARP00000132417 | ENSDARP00000144951 | ATP-binding cassette, sub-family A (ABC1), member 1A. | Niemann-Pick disease, type C1. | 0.593 |
abca1a | srebf2 | ENSDARP00000132417 | ENSDARP00000087122 | ATP-binding cassette, sub-family A (ABC1), member 1A. | Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity). | 0.846 |
abcg1 | abca1a | ENSDARP00000087241 | ENSDARP00000132417 | ATP-binding cassette, sub-family G (WHITE), member 1. | ATP-binding cassette, sub-family A (ABC1), member 1A. | 0.496 |
abcg1 | fasn | ENSDARP00000087241 | ENSDARP00000112100 | ATP-binding cassette, sub-family G (WHITE), member 1. | Coiled-coil domain containing 57. | 0.403 |
abcg1 | hmgcra | ENSDARP00000087241 | ENSDARP00000088231 | ATP-binding cassette, sub-family G (WHITE), member 1. | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 0.468 |
abcg1 | npc1 | ENSDARP00000087241 | ENSDARP00000144951 | ATP-binding cassette, sub-family G (WHITE), member 1. | Niemann-Pick disease, type C1. | 0.635 |
abcg1 | srebf2 | ENSDARP00000087241 | ENSDARP00000087122 | ATP-binding cassette, sub-family G (WHITE), member 1. | Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity). | 0.844 |
fasn | abca1a | ENSDARP00000112100 | ENSDARP00000132417 | Coiled-coil domain containing 57. | ATP-binding cassette, sub-family A (ABC1), member 1A. | 0.619 |
fasn | abcg1 | ENSDARP00000112100 | ENSDARP00000087241 | Coiled-coil domain containing 57. | ATP-binding cassette, sub-family G (WHITE), member 1. | 0.403 |
fasn | hmgcra | ENSDARP00000112100 | ENSDARP00000088231 | Coiled-coil domain containing 57. | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 0.813 |
fasn | hmgcs1 | ENSDARP00000112100 | ENSDARP00000137373 | Coiled-coil domain containing 57. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.854 |
fasn | srebf2 | ENSDARP00000112100 | ENSDARP00000087122 | Coiled-coil domain containing 57. | Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity). | 0.885 |
hmgcra | abca1a | ENSDARP00000088231 | ENSDARP00000132417 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | ATP-binding cassette, sub-family A (ABC1), member 1A. | 0.604 |
hmgcra | abcg1 | ENSDARP00000088231 | ENSDARP00000087241 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | ATP-binding cassette, sub-family G (WHITE), member 1. | 0.468 |
hmgcra | fasn | ENSDARP00000088231 | ENSDARP00000112100 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | Coiled-coil domain containing 57. | 0.813 |
hmgcra | hmgcs1 | ENSDARP00000088231 | ENSDARP00000137373 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.999 |