node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP6 | atp23 | ENSDARP00000087874 | ENSDARP00000087721 | ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] | Mitochondrial inner membrane protease ATP23 homolog; Belongs to the peptidase M76 family. | 0.825 |
ATP6 | cox11 | ENSDARP00000087874 | ENSDARP00000080966 | ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] | Cytochrome c oxidase assembly homolog 11 (yeast). | 0.693 |
ATP6 | oma1 | ENSDARP00000087874 | ENSDARP00000119103 | ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of opa1 at S1 position, leading to opa1 inactivation and negative regulation of mitochondrial fusion. | 0.472 |
atp23 | ATP6 | ENSDARP00000087721 | ENSDARP00000087874 | Mitochondrial inner membrane protease ATP23 homolog; Belongs to the peptidase M76 family. | ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] | 0.825 |
atp23 | chchd4a | ENSDARP00000087721 | ENSDARP00000039846 | Mitochondrial inner membrane protease ATP23 homolog; Belongs to the peptidase M76 family. | Mitochondrial intermembrane space import and assembly protein 40; Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (By similarity). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitoc [...] | 0.949 |
atp23 | ciapin1 | ENSDARP00000087721 | ENSDARP00000105419 | Mitochondrial inner membrane protease ATP23 homolog; Belongs to the peptidase M76 family. | Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] | 0.763 |
atp23 | coa7 | ENSDARP00000087721 | ENSDARP00000026471 | Mitochondrial inner membrane protease ATP23 homolog; Belongs to the peptidase M76 family. | Cytochrome c oxidase assembly factor 7; May be required for assembly of mitochondrial respiratory chain complexes; Belongs to the hcp beta-lactamase family. | 0.873 |
atp23 | cox11 | ENSDARP00000087721 | ENSDARP00000080966 | Mitochondrial inner membrane protease ATP23 homolog; Belongs to the peptidase M76 family. | Cytochrome c oxidase assembly homolog 11 (yeast). | 0.709 |
atp23 | gfer | ENSDARP00000087721 | ENSDARP00000093302 | Mitochondrial inner membrane protease ATP23 homolog; Belongs to the peptidase M76 family. | Sulfhydryl oxidase. | 0.825 |
atp23 | lancl2 | ENSDARP00000087721 | ENSDARP00000091190 | Mitochondrial inner membrane protease ATP23 homolog; Belongs to the peptidase M76 family. | LanC lantibiotic synthetase component C-like 2 (bacterial). | 0.745 |
atp23 | oma1 | ENSDARP00000087721 | ENSDARP00000119103 | Mitochondrial inner membrane protease ATP23 homolog; Belongs to the peptidase M76 family. | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of opa1 at S1 position, leading to opa1 inactivation and negative regulation of mitochondrial fusion. | 0.899 |
atp23 | phb | ENSDARP00000087721 | ENSDARP00000074525 | Mitochondrial inner membrane protease ATP23 homolog; Belongs to the peptidase M76 family. | Prohibitin. | 0.769 |
atp23 | timm10 | ENSDARP00000087721 | ENSDARP00000091094 | Mitochondrial inner membrane protease ATP23 homolog; Belongs to the peptidase M76 family. | Mitochondrial import inner membrane translocase subunit Tim10; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family. | 0.843 |
chchd4a | atp23 | ENSDARP00000039846 | ENSDARP00000087721 | Mitochondrial intermembrane space import and assembly protein 40; Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (By similarity). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitoc [...] | Mitochondrial inner membrane protease ATP23 homolog; Belongs to the peptidase M76 family. | 0.949 |
chchd4a | ciapin1 | ENSDARP00000039846 | ENSDARP00000105419 | Mitochondrial intermembrane space import and assembly protein 40; Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (By similarity). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitoc [...] | Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] | 0.608 |
chchd4a | coa7 | ENSDARP00000039846 | ENSDARP00000026471 | Mitochondrial intermembrane space import and assembly protein 40; Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (By similarity). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitoc [...] | Cytochrome c oxidase assembly factor 7; May be required for assembly of mitochondrial respiratory chain complexes; Belongs to the hcp beta-lactamase family. | 0.857 |
chchd4a | cox11 | ENSDARP00000039846 | ENSDARP00000080966 | Mitochondrial intermembrane space import and assembly protein 40; Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (By similarity). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitoc [...] | Cytochrome c oxidase assembly homolog 11 (yeast). | 0.847 |
chchd4a | gfer | ENSDARP00000039846 | ENSDARP00000093302 | Mitochondrial intermembrane space import and assembly protein 40; Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (By similarity). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitoc [...] | Sulfhydryl oxidase. | 0.994 |
chchd4a | oma1 | ENSDARP00000039846 | ENSDARP00000119103 | Mitochondrial intermembrane space import and assembly protein 40; Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (By similarity). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitoc [...] | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of opa1 at S1 position, leading to opa1 inactivation and negative regulation of mitochondrial fusion. | 0.438 |
chchd4a | timm10 | ENSDARP00000039846 | ENSDARP00000091094 | Mitochondrial intermembrane space import and assembly protein 40; Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (By similarity). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitoc [...] | Mitochondrial import inner membrane translocase subunit Tim10; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family. | 0.964 |