STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppargc1aPeroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (859 aa)    
Predicted Functional Partners:
esrra
Estrogen-related receptor alpha.
   
 
 0.972
pparg
Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]
   
 
 0.936
nr3c1
Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).
   
 
 0.926
cwc15
Protein CWC15 homolog; Involved in pre-mRNA splicing as component of the spliceosome.
   
 
 0.906
pparaa
Peroxisome proliferator-activated receptor alpha a.
   
 
 0.902
pparab
Peroxisome proliferator-activated receptor alpha b.
   
 
 0.899
crnkl1
Crooked neck pre-mRNA-splicing factor 1.
   
 
 0.880
cdc40
Cell division cycle 40 homolog (S. cerevisiae).
   
 
 0.876
cdc5l
CDC5 cell division cycle 5-like (S. pombe).
   
 
 0.876
bud31
Protein BUD31 homolog; Involved in pre-mRNA splicing process.
   
 
 0.872
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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