STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
serpini1Serpin peptidase inhibitor, clade I (neuroserpin), member 1; Belongs to the serpin family. (415 aa)    
Predicted Functional Partners:
tmco4
Transmembrane and coiled-coil domains 4.
      
 0.801
tmem176l.1
Transmembrane protein 176l.1.
      
 0.719
psd3l
Pleckstrin and Sec7 domain-containing 3,-like.
      
 0.718
pdcd10a
Programmed cell death protein 10-A; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development.
 
 
  
 0.708
otomp
Otolith matrix protein 1; Required for normal otolith growth and deposition of otolin-1 in the otolith.
   
 
 0.677
epdl1
Ependymin-like 1.
      
 0.650
oacyl
O-acyltransferase-like.
      
 0.645
pcsk1nl
Proprotein convertase subtilisin/kexin type 1 inhibitor,-like.
   
  
 0.638
zcchc2
Zinc finger, CCHC domain-containing 2.
      
 0.605
stm
Protein starmaker; Essential for the formation of otoliths in the inner ear of developing larvae and for the perception of gravity and acceleration. May be one of the organic components of the ortholiths.
      
 0.600
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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