node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
comtb | cyp1a | ENSDARP00000038939 | ENSDARP00000139599 | Catechol O-methyltransferase B; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | 0.930 |
comtb | cyp1b1 | ENSDARP00000038939 | ENSDARP00000107132 | Catechol O-methyltransferase B; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.925 |
comtb | tomt | ENSDARP00000038939 | ENSDARP00000145949 | Catechol O-methyltransferase B; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | Transmembrane O-methyltransferase homolog; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function. Component of the hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity. | 0.904 |
cyp1a | comtb | ENSDARP00000139599 | ENSDARP00000038939 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | Catechol O-methyltransferase B; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | 0.930 |
cyp1a | cyp1b1 | ENSDARP00000139599 | ENSDARP00000107132 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.931 |
cyp1a | ephx1 | ENSDARP00000139599 | ENSDARP00000062897 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.980 |
cyp1a | hsd17b1 | ENSDARP00000139599 | ENSDARP00000026566 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.927 |
cyp1a | hsd17b12a | ENSDARP00000139599 | ENSDARP00000014003 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | Very-long-chain 3-oxoacyl-CoA reductase-A; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of memb [...] | 0.934 |
cyp1a | hsd17b12b | ENSDARP00000139599 | ENSDARP00000089612 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | Very-long-chain 3-oxoacyl-CoA reductase-B; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of memb [...] | 0.933 |
cyp1a | hsd17b7 | ENSDARP00000139599 | ENSDARP00000098015 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 7. | 0.939 |
cyp1a | hsd17b8 | ENSDARP00000139599 | ENSDARP00000001459 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | FabG (Beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like. | 0.928 |
cyp1a | ido1 | ENSDARP00000139599 | ENSDARP00000056360 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | Indoleamine 2,3-dioxygenase 1. | 0.938 |
cyp1a | tomt | ENSDARP00000139599 | ENSDARP00000145949 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | Transmembrane O-methyltransferase homolog; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function. Component of the hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity. | 0.954 |
cyp1b1 | comtb | ENSDARP00000107132 | ENSDARP00000038939 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Catechol O-methyltransferase B; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. | 0.925 |
cyp1b1 | cyp1a | ENSDARP00000107132 | ENSDARP00000139599 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | 0.931 |
cyp1b1 | ephx1 | ENSDARP00000107132 | ENSDARP00000062897 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.966 |
cyp1b1 | hsd17b1 | ENSDARP00000107132 | ENSDARP00000026566 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.938 |
cyp1b1 | hsd17b12a | ENSDARP00000107132 | ENSDARP00000014003 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Very-long-chain 3-oxoacyl-CoA reductase-A; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of memb [...] | 0.939 |
cyp1b1 | hsd17b12b | ENSDARP00000107132 | ENSDARP00000089612 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Very-long-chain 3-oxoacyl-CoA reductase-B; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of memb [...] | 0.938 |
cyp1b1 | hsd17b7 | ENSDARP00000107132 | ENSDARP00000098015 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 7. | 0.932 |