STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glcebD-glucuronyl C5-epimerase B; Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. Plays a role in dorso-ventral axis specification during early development, together with glcea, where it may potentiate signaling via the BMP pathway. (586 aa)    
Predicted Functional Partners:
ndst1a
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1a.
   
 0.988
ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3.
   
 0.985
ndst2b
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2b.
   
 0.975
ndst1b
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1b.
   
 0.974
glcea
Glucuronic acid epimerase a.
  
  
0.903
hs6st2
Heparan-sulfate 6-O-sulfotransferase 2; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Required for muscle development and angiogenesis.
   
 
 0.822
hs3st1l2
Sulfotransferase; Belongs to the sulfotransferase 1 family.
      
 0.707
extl3
Exostosin-like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family.
   
  
 0.698
hs6st1a
Heparan-sulfate 6-O-sulfotransferase 1-A; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
   
 
 0.694
chst3a
Sulfotransferase; Belongs to the sulfotransferase 1 family.
      
 0.670
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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