node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HACD4 | hsd20b2 | ENSDARP00000132812 | ENSDARP00000091542 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] | 20beta-hydroxysteroid dehydrogenase type 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.958 |
cyp19a1a | cyp1b1 | ENSDARP00000111604 | ENSDARP00000107132 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.636 |
cyp19a1a | cyp3a65 | ENSDARP00000111604 | ENSDARP00000137034 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Cytochrome P450, family 3, subfamily A, polypeptide 65; Belongs to the cytochrome P450 family. | 0.952 |
cyp19a1a | hsd17b1 | ENSDARP00000111604 | ENSDARP00000026566 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Hydroxysteroid (17-beta) dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.988 |
cyp19a1a | hsd17b7 | ENSDARP00000111604 | ENSDARP00000098015 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Hydroxysteroid (17-beta) dehydrogenase 7. | 0.959 |
cyp19a1a | hsd17b8 | ENSDARP00000111604 | ENSDARP00000001459 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | FabG (Beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like. | 0.944 |
cyp19a1a | hsd20b2 | ENSDARP00000111604 | ENSDARP00000091542 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 20beta-hydroxysteroid dehydrogenase type 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.945 |
cyp1b1 | cyp19a1a | ENSDARP00000107132 | ENSDARP00000111604 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.636 |
cyp1b1 | cyp3a65 | ENSDARP00000107132 | ENSDARP00000137034 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Cytochrome P450, family 3, subfamily A, polypeptide 65; Belongs to the cytochrome P450 family. | 0.617 |
cyp1b1 | hsd17b1 | ENSDARP00000107132 | ENSDARP00000026566 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.938 |
cyp1b1 | hsd17b7 | ENSDARP00000107132 | ENSDARP00000098015 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 7. | 0.932 |
cyp1b1 | hsd17b8 | ENSDARP00000107132 | ENSDARP00000001459 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | FabG (Beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like. | 0.935 |
cyp1b1 | hsd20b2 | ENSDARP00000107132 | ENSDARP00000091542 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 20beta-hydroxysteroid dehydrogenase type 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.920 |
cyp3a65 | cyp19a1a | ENSDARP00000137034 | ENSDARP00000111604 | Cytochrome P450, family 3, subfamily A, polypeptide 65; Belongs to the cytochrome P450 family. | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.952 |
cyp3a65 | cyp1b1 | ENSDARP00000137034 | ENSDARP00000107132 | Cytochrome P450, family 3, subfamily A, polypeptide 65; Belongs to the cytochrome P450 family. | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.617 |
cyp3a65 | hsd17b1 | ENSDARP00000137034 | ENSDARP00000026566 | Cytochrome P450, family 3, subfamily A, polypeptide 65; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.916 |
cyp3a65 | hsd17b7 | ENSDARP00000137034 | ENSDARP00000098015 | Cytochrome P450, family 3, subfamily A, polypeptide 65; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 7. | 0.919 |
cyp3a65 | hsd17b8 | ENSDARP00000137034 | ENSDARP00000001459 | Cytochrome P450, family 3, subfamily A, polypeptide 65; Belongs to the cytochrome P450 family. | FabG (Beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like. | 0.921 |
cyp3a65 | hsd20b2 | ENSDARP00000137034 | ENSDARP00000091542 | Cytochrome P450, family 3, subfamily A, polypeptide 65; Belongs to the cytochrome P450 family. | 20beta-hydroxysteroid dehydrogenase type 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.924 |
hacd1 | hsd20b2 | ENSDARP00000138307 | ENSDARP00000091542 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] | 20beta-hydroxysteroid dehydrogenase type 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.958 |