node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
anapc11 | rbx1 | ENSDARP00000130416 | ENSDARP00000055431 | APC11 anaphase-promoting complex subunit 11 homolog (yeast). | Ring-box 1, E3 ubiquitin protein ligase. | 0.732 |
anapc11 | rps27a | ENSDARP00000130416 | ENSDARP00000128775 | APC11 anaphase-promoting complex subunit 11 homolog (yeast). | Ribosomal protein S27a. | 0.612 |
anapc11 | ube2d3 | ENSDARP00000130416 | ENSDARP00000093157 | APC11 anaphase-promoting complex subunit 11 homolog (yeast). | Ubiquitin-conjugating enzyme E2D 3; Belongs to the ubiquitin-conjugating enzyme family. | 0.665 |
cops3 | crbn | ENSDARP00000021983 | ENSDARP00000062723 | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. | 0.685 |
cops3 | rbx1 | ENSDARP00000021983 | ENSDARP00000055431 | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). | Ring-box 1, E3 ubiquitin protein ligase. | 0.909 |
cops3 | rps27a | ENSDARP00000021983 | ENSDARP00000128775 | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). | Ribosomal protein S27a. | 0.599 |
cops3 | ube2d3 | ENSDARP00000021983 | ENSDARP00000093157 | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). | Ubiquitin-conjugating enzyme E2D 3; Belongs to the ubiquitin-conjugating enzyme family. | 0.658 |
crbn | cops3 | ENSDARP00000062723 | ENSDARP00000021983 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). | 0.685 |
crbn | rbx1 | ENSDARP00000062723 | ENSDARP00000055431 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. | Ring-box 1, E3 ubiquitin protein ligase. | 0.974 |
crbn | uba1 | ENSDARP00000062723 | ENSDARP00000054690 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. | Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | 0.500 |
crbn | ube2d3 | ENSDARP00000062723 | ENSDARP00000093157 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. | Ubiquitin-conjugating enzyme E2D 3; Belongs to the ubiquitin-conjugating enzyme family. | 0.659 |
rbx1 | anapc11 | ENSDARP00000055431 | ENSDARP00000130416 | Ring-box 1, E3 ubiquitin protein ligase. | APC11 anaphase-promoting complex subunit 11 homolog (yeast). | 0.732 |
rbx1 | cops3 | ENSDARP00000055431 | ENSDARP00000021983 | Ring-box 1, E3 ubiquitin protein ligase. | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). | 0.909 |
rbx1 | crbn | ENSDARP00000055431 | ENSDARP00000062723 | Ring-box 1, E3 ubiquitin protein ligase. | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. | 0.974 |
rbx1 | rps27a | ENSDARP00000055431 | ENSDARP00000128775 | Ring-box 1, E3 ubiquitin protein ligase. | Ribosomal protein S27a. | 0.923 |
rbx1 | uba1 | ENSDARP00000055431 | ENSDARP00000054690 | Ring-box 1, E3 ubiquitin protein ligase. | Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | 0.682 |
rbx1 | uba52 | ENSDARP00000055431 | ENSDARP00000060744 | Ring-box 1, E3 ubiquitin protein ligase. | Ubiquitin A-52 residue ribosomal protein fusion product 1. | 0.870 |
rbx1 | ube2d3 | ENSDARP00000055431 | ENSDARP00000093157 | Ring-box 1, E3 ubiquitin protein ligase. | Ubiquitin-conjugating enzyme E2D 3; Belongs to the ubiquitin-conjugating enzyme family. | 0.645 |
rps27a | anapc11 | ENSDARP00000128775 | ENSDARP00000130416 | Ribosomal protein S27a. | APC11 anaphase-promoting complex subunit 11 homolog (yeast). | 0.612 |
rps27a | cops3 | ENSDARP00000128775 | ENSDARP00000021983 | Ribosomal protein S27a. | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). | 0.599 |