STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fbxo9F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling. (421 aa)    
Predicted Functional Partners:
skp1
S-phase kinase-associated protein 1A; Belongs to the SKP1 family.
   
 0.983
cul1a
Cullin 1a; Belongs to the cullin family.
    
 0.836
cul1b
Cullin 1b; Belongs to the cullin family.
   
 
 0.765
ubox5
U-box domain-containing 5.
   
  
 0.754
fbxl14b
F-box and leucine-rich repeat protein 14b.
    
 0.719
fbxl4
F-box and leucine-rich repeat protein 4.
   
 0.708
cul3a
Cullin 3a; Belongs to the cullin family.
   
 
 0.701
cul3b
Cullin 3b; Belongs to the cullin family.
    
 
 0.696
fbxl14a
F-box and leucine-rich repeat protein 14a.
    
 
 0.695
cops4
COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
   
 
 0.679
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.