STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnajc2DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription ac [...] (618 aa)    
Predicted Functional Partners:
zpr1
ZPR1 zinc finger.
   
  
 0.904
hsp70.3
Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family.
   
 0.898
hspa14
Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding- competent state.
   
 0.872
hsp70l
Novel protein similar to heat shock cognate 70-kd protein; Belongs to the heat shock protein 70 family.
   
 0.839
gfap
Glial fibrillary acidic protein; Belongs to the intermediate filament family.
    
 
 0.837
hsp70.1
Heat shock cognate 70-kd protein, tandem duplicate 1; Belongs to the heat shock protein 70 family.
   
 
 0.837
elavl3
ELAV-like protein; Belongs to the RRM elav family.
   
  
 0.833
hspa8b
Si:dkey-4p15.3; Belongs to the heat shock protein 70 family.
   
 0.809
hspa8
Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]
   
 0.809
hsp70.2
Heat shock cognate 70-kd protein, tandem duplicate 2; Belongs to the heat shock protein 70 family.
   
 0.809
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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