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tdp2b protein (Danio rerio) - STRING interaction network
"tdp2b" - Tyrosyl-DNA phosphodiesterase 2 in Danio rerio
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tdp2bTyrosyl-DNA phosphodiesterase 2; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5’-phosphodiester bond, giving rise to DNA with a free 5’ phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5’- phosphoglycolates on protruding 5’ ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals (By similarity). Controls gastrulation movements and left/right (L/R) axis determination via smad3-mediated regulation of cdh1/e- cadh [...] (383 aa)    
Predicted Functional Partners:
exosc4
Exosome complex exonuclease RRP41; Exosome component 4 (245 aa)
     
      0.909
exosc3
Exosome component 3 (247 aa)
     
      0.904
dis3
DIS3 exosome endoribonuclease and 3’-5’ exoribonuclease; DIS3 mitotic control homolog (S. cerevisiae); Belongs to the RNR ribonuclease family (950 aa)
     
      0.903
dis3l
DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events (1057 aa)
     
      0.903
tdp1
tyrosyl-DNA phosphodiesterase 1 (615 aa)
     
   
  0.889
cd40
CD40 molecule, TNF receptor superfamily member 5; CD40 antigen (286 aa)
       
 
  0.820
htr1aa
5-hydroxytryptamine (serotonin) receptor 1A a (398 aa)
           
  0.812
acot13
acyl-CoA thioesterase 13 (146 aa)
     
   
  0.787
uggt2
UDP-glucose glycoprotein glucosyltransferase 2 (1527 aa)
     
   
  0.748
ypel3
Protein yippee-like 3; May be involved in proliferation and apoptosis in myeloid precursor cells (119 aa)
     
   
  0.743
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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