node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dll4 | hey1 | ENSDARP00000094097 | ENSDARP00000094416 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. | 0.903 |
dll4 | hey2 | ENSDARP00000094097 | ENSDARP00000002357 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Hairy/enhancer-of-split related with YRPW motif protein 2; Transcriptional repressor (By similarity). Downstream effector of Notch signaling which regulates cell fate choice in angioblasts. Represses the venous cell fate, thereby promoting the arterial cell fate and aorta formation; Belongs to the HEY family. | 0.925 |
dll4 | heyl | ENSDARP00000094097 | ENSDARP00000072659 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Hairy/enhancer-of-split related with YRPW motif-like protein; Transcriptional repressor which functions as a downstream effector of Notch signaling. | 0.574 |
dll4 | jag1b | ENSDARP00000094097 | ENSDARP00000008197 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | 0.401 |
dll4 | notch1a | ENSDARP00000094097 | ENSDARP00000137942 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.990 |
dll4 | notch2 | ENSDARP00000094097 | ENSDARP00000112112 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Notch receptor 2. | 0.924 |
dll4 | notch3 | ENSDARP00000094097 | ENSDARP00000068420 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Notch receptor 3. | 0.792 |
dll4 | rbpja | ENSDARP00000094097 | ENSDARP00000026585 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Recombination signal-binding protein for immunoglobulin kappa J region a. | 0.878 |
hey1 | dll4 | ENSDARP00000094416 | ENSDARP00000094097 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | 0.903 |
hey1 | hey2 | ENSDARP00000094416 | ENSDARP00000002357 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. | Hairy/enhancer-of-split related with YRPW motif protein 2; Transcriptional repressor (By similarity). Downstream effector of Notch signaling which regulates cell fate choice in angioblasts. Represses the venous cell fate, thereby promoting the arterial cell fate and aorta formation; Belongs to the HEY family. | 0.911 |
hey1 | heyl | ENSDARP00000094416 | ENSDARP00000072659 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. | Hairy/enhancer-of-split related with YRPW motif-like protein; Transcriptional repressor which functions as a downstream effector of Notch signaling. | 0.912 |
hey1 | jag1a | ENSDARP00000094416 | ENSDARP00000121170 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | 0.938 |
hey1 | jag1b | ENSDARP00000094416 | ENSDARP00000008197 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | 0.864 |
hey1 | jag2b | ENSDARP00000094416 | ENSDARP00000010799 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | 0.840 |
hey1 | notch1a | ENSDARP00000094416 | ENSDARP00000137942 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.957 |
hey1 | notch2 | ENSDARP00000094416 | ENSDARP00000112112 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. | Notch receptor 2. | 0.838 |
hey1 | notch3 | ENSDARP00000094416 | ENSDARP00000068420 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. | Notch receptor 3. | 0.816 |
hey1 | rbpja | ENSDARP00000094416 | ENSDARP00000026585 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. | Recombination signal-binding protein for immunoglobulin kappa J region a. | 0.855 |
hey2 | dll4 | ENSDARP00000002357 | ENSDARP00000094097 | Hairy/enhancer-of-split related with YRPW motif protein 2; Transcriptional repressor (By similarity). Downstream effector of Notch signaling which regulates cell fate choice in angioblasts. Represses the venous cell fate, thereby promoting the arterial cell fate and aorta formation; Belongs to the HEY family. | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | 0.925 |
hey2 | hey1 | ENSDARP00000002357 | ENSDARP00000094416 | Hairy/enhancer-of-split related with YRPW motif protein 2; Transcriptional repressor (By similarity). Downstream effector of Notch signaling which regulates cell fate choice in angioblasts. Represses the venous cell fate, thereby promoting the arterial cell fate and aorta formation; Belongs to the HEY family. | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. | 0.911 |