node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
coro7 | kbtbd8 | ENSDARP00000139047 | ENSDARP00000094847 | Coronin; Belongs to the WD repeat coronin family. | Kelch repeat and BTB domain-containing protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (By similarity). The BCR(KBTBD8) complex acts by mediating monoubiquitination of target proteins (By similarity). | 0.811 |
coro7 | spopla | ENSDARP00000139047 | ENSDARP00000026361 | Coronin; Belongs to the WD repeat coronin family. | Speckle-type POZ protein-like A; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency; Belongs to the Tdpoz family. | 0.576 |
cul3a | cul3b | ENSDARP00000056881 | ENSDARP00000132246 | Cullin 3a; Belongs to the cullin family. | Cullin 3b; Belongs to the cullin family. | 0.900 |
cul3a | kbtbd8 | ENSDARP00000056881 | ENSDARP00000094847 | Cullin 3a; Belongs to the cullin family. | Kelch repeat and BTB domain-containing protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (By similarity). The BCR(KBTBD8) complex acts by mediating monoubiquitination of target proteins (By similarity). | 0.962 |
cul3a | klhl12 | ENSDARP00000056881 | ENSDARP00000131425 | Cullin 3a; Belongs to the cullin family. | Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity). Negatively regulates the Wnt signaling pathway, possibly via the targeted ubiquitination and subsequent proteolysis of dvl2 and dvl3. Regulates convergent-extension movements during early [...] | 0.994 |
cul3a | klhl3 | ENSDARP00000056881 | ENSDARP00000142614 | Cullin 3a; Belongs to the cullin family. | Kelch-like protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. | 0.945 |
cul3a | klhl40a | ENSDARP00000056881 | ENSDARP00000057021 | Cullin 3a; Belongs to the cullin family. | Kelch-like protein 40a; ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development ; Belongs to the KLHL40 family. | 0.655 |
cul3a | klhl40b | ENSDARP00000056881 | ENSDARP00000012991 | Cullin 3a; Belongs to the cullin family. | Kelch-like protein 40b; ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development ; Belongs to the KLHL40 family. | 0.655 |
cul3a | nolc1 | ENSDARP00000056881 | ENSDARP00000093426 | Cullin 3a; Belongs to the cullin family. | Nucleolar and coiled-body phosphoprotein 1. | 0.414 |
cul3a | pef1 | ENSDARP00000056881 | ENSDARP00000033243 | Cullin 3a; Belongs to the cullin family. | Peflin; Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Acts as a negative regulator of ER-Golgi transport (By similarity). | 0.900 |
cul3a | spopla | ENSDARP00000056881 | ENSDARP00000026361 | Cullin 3a; Belongs to the cullin family. | Speckle-type POZ protein-like A; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency; Belongs to the Tdpoz family. | 0.994 |
cul3b | cul3a | ENSDARP00000132246 | ENSDARP00000056881 | Cullin 3b; Belongs to the cullin family. | Cullin 3a; Belongs to the cullin family. | 0.900 |
cul3b | kbtbd8 | ENSDARP00000132246 | ENSDARP00000094847 | Cullin 3b; Belongs to the cullin family. | Kelch repeat and BTB domain-containing protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (By similarity). The BCR(KBTBD8) complex acts by mediating monoubiquitination of target proteins (By similarity). | 0.962 |
cul3b | klhl12 | ENSDARP00000132246 | ENSDARP00000131425 | Cullin 3b; Belongs to the cullin family. | Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity). Negatively regulates the Wnt signaling pathway, possibly via the targeted ubiquitination and subsequent proteolysis of dvl2 and dvl3. Regulates convergent-extension movements during early [...] | 0.994 |
cul3b | klhl3 | ENSDARP00000132246 | ENSDARP00000142614 | Cullin 3b; Belongs to the cullin family. | Kelch-like protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. | 0.945 |
cul3b | klhl40a | ENSDARP00000132246 | ENSDARP00000057021 | Cullin 3b; Belongs to the cullin family. | Kelch-like protein 40a; ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development ; Belongs to the KLHL40 family. | 0.655 |
cul3b | klhl40b | ENSDARP00000132246 | ENSDARP00000012991 | Cullin 3b; Belongs to the cullin family. | Kelch-like protein 40b; ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development ; Belongs to the KLHL40 family. | 0.655 |
cul3b | nolc1 | ENSDARP00000132246 | ENSDARP00000093426 | Cullin 3b; Belongs to the cullin family. | Nucleolar and coiled-body phosphoprotein 1. | 0.412 |
cul3b | pef1 | ENSDARP00000132246 | ENSDARP00000033243 | Cullin 3b; Belongs to the cullin family. | Peflin; Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Acts as a negative regulator of ER-Golgi transport (By similarity). | 0.900 |
cul3b | spopla | ENSDARP00000132246 | ENSDARP00000026361 | Cullin 3b; Belongs to the cullin family. | Speckle-type POZ protein-like A; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency; Belongs to the Tdpoz family. | 0.994 |