node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ddhd1b | ero1a | ENSDARP00000053840 | ENSDARP00000015478 | DDHD domain-containing 1b. | ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the folding of immunoglobulins (By similarity). Belongs to the EROs family. | 0.445 |
ddhd1b | gng2 | ENSDARP00000053840 | ENSDARP00000073854 | DDHD domain-containing 1b. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.445 |
ddhd1b | gpr137c | ENSDARP00000053840 | ENSDARP00000066603 | DDHD domain-containing 1b. | G protein-coupled receptor 137ba. | 0.654 |
ddhd1b | psmc6 | ENSDARP00000053840 | ENSDARP00000053833 | DDHD domain-containing 1b. | Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. | 0.496 |
ddhd1b | styx | ENSDARP00000053840 | ENSDARP00000028338 | DDHD domain-containing 1b. | Serine/threonine/tyrosine-interacting protein. | 0.663 |
ddhd1b | txndc16 | ENSDARP00000053840 | ENSDARP00000095835 | DDHD domain-containing 1b. | Thioredoxin domain-containing 16. | 0.814 |
ero1a | ddhd1b | ENSDARP00000015478 | ENSDARP00000053840 | ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the folding of immunoglobulins (By similarity). Belongs to the EROs family. | DDHD domain-containing 1b. | 0.445 |
ero1a | gng2 | ENSDARP00000015478 | ENSDARP00000073854 | ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the folding of immunoglobulins (By similarity). Belongs to the EROs family. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.461 |
ero1a | gpr137c | ENSDARP00000015478 | ENSDARP00000066603 | ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the folding of immunoglobulins (By similarity). Belongs to the EROs family. | G protein-coupled receptor 137ba. | 0.619 |
ero1a | psmc6 | ENSDARP00000015478 | ENSDARP00000053833 | ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the folding of immunoglobulins (By similarity). Belongs to the EROs family. | Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. | 0.442 |
ero1a | styx | ENSDARP00000015478 | ENSDARP00000028338 | ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the folding of immunoglobulins (By similarity). Belongs to the EROs family. | Serine/threonine/tyrosine-interacting protein. | 0.612 |
ero1a | txndc16 | ENSDARP00000015478 | ENSDARP00000095835 | ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the folding of immunoglobulins (By similarity). Belongs to the EROs family. | Thioredoxin domain-containing 16. | 0.885 |
foxred2 | txndc16 | ENSDARP00000150274 | ENSDARP00000095835 | FAD-dependent oxidoreductase domain-containing protein 2; Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation (By similarity); Belongs to the FOXRED2 family. | Thioredoxin domain-containing 16. | 0.621 |
gng2 | ddhd1b | ENSDARP00000073854 | ENSDARP00000053840 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | DDHD domain-containing 1b. | 0.445 |
gng2 | ero1a | ENSDARP00000073854 | ENSDARP00000015478 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the folding of immunoglobulins (By similarity). Belongs to the EROs family. | 0.461 |
gng2 | gpr137c | ENSDARP00000073854 | ENSDARP00000066603 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | G protein-coupled receptor 137ba. | 0.582 |
gng2 | psmc6 | ENSDARP00000073854 | ENSDARP00000053833 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. | 0.408 |
gng2 | ptger2a | ENSDARP00000073854 | ENSDARP00000112192 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Prostaglandin E2 receptor subtype EP2-like; Belongs to the G-protein coupled receptor 1 family. | 0.416 |
gng2 | styx | ENSDARP00000073854 | ENSDARP00000028338 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Serine/threonine/tyrosine-interacting protein. | 0.603 |
gng2 | txndc16 | ENSDARP00000073854 | ENSDARP00000095835 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Thioredoxin domain-containing 16. | 0.808 |