STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
asic1aAcid-sensing ion channel 1A; Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. (501 aa)    
Predicted Functional Partners:
p2rx4a
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
      
 0.650
stoml3a
Stomatin (EPB72)-like 3a.
   
 0.615
stom
Stomatin.
    
 0.611
stoml3b
Stomatin (EPB72)-like 3b.
    
 0.611
p2rx3a
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
      
 0.602
gak
Cyclin G-associated kinase.
      
 0.580
kcnj1a.1
Potassium inwardly rectifying channel subfamily J member 1a, tandem duplicate 1.
      
 0.543
trpv1
Transient receptor potential cation channel, subfamily V, member 1; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.541
kcnk2b
Potassium channel, subfamily K, member 2b; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
      
 0.525
asic2
Acid-sensing ion channel 2; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity.
  
  
0.517
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (30%) [HD]