STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aceAngiotensin-converting enzyme. (1324 aa)    
Predicted Functional Partners:
agt
Angiotensinogen; Belongs to the serpin family.
    
 0.986
ren
Renin; Belongs to the peptidase A1 family.
      
 0.962
mmel1
Membrane metallo-endopeptidase-like 1.
      
 0.785
agtr1a
Angiotensin II receptor, type 1a; Belongs to the G-protein coupled receptor 1 family.
      
 0.764
nr3c2
Nuclear receptor subfamily 3, group C, member 2.
   
  
 0.732
agtr1b
Angiotensin II receptor, type 1b; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.713
edn1
Endothelin 1.
      
 0.691
agtr2
Angiotensin II receptor, type 2; Belongs to the G-protein coupled receptor 1 family.
      
 0.671
ece2b
Endothelin-converting enzyme 2b.
      
 0.625
ins
Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
   
  
 0.616
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.