STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gpr183bG-protein coupled receptor 183-B; Probable receptor for oxysterols that plays a central role during humoral immunity. Promotes activated B-cell localization in the outer follicle and interfollicular regions (By similarity) (366 aa)    
Predicted Functional Partners:
s1pr2
Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P receptor is critical for cell migration and epithlial integrity during vertebrate embryogenesis
     
 0.940
s1pr1
Sphingosine 1-phosphate receptor 1; G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate
   
 
 0.921
ccr7
Chemokine (C-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family
   
 
0.917
CXCR5
Chemokine (C-X-C motif) receptor 5; Belongs to the G-protein coupled receptor 1 family
   
 
0.913
gpr18
G protein-coupled receptor 18
   
 
0.912
lpar2a
Lysophosphatidic acid receptor 2a; Belongs to the G-protein coupled receptor 1 family
     
 0.911
lpar2b
Lysophosphatidic acid receptor 2b; Belongs to the G-protein coupled receptor 1 family
     
 0.911
gnai2a
Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a
     
 0.911
gnai2b
Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
     
 0.911
GPR17
G protein-coupled receptor 17
     
0.910
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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