STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kcnj3aPotassium inwardly rectifying channel subfamily J member 3a. (490 aa)    
Predicted Functional Partners:
gnb2
Guanine nucleotide-binding protein (G protein), beta polypeptide 2.
   
 
 0.789
orai1a
ORAI calcium release-activated calcium modulator 1a.
      
 0.743
stim1a
Stromal interaction molecule 1a.
      
 0.647
orai1b
Calcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores; Belongs to the Orai family.
      
 0.585
hcn4
Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4.
   
  
 0.505
shox2
Short stature homeobox 2.
   
  
 0.484
stim1b
Stromal interaction molecule 1b.
      
 0.441
ryr2b
Ryanodine receptor 2b (cardiac).
   
  
 0.420
gnb5b
Guanine nucleotide-binding protein subunit beta-5b; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). Along with gnb5b, plays an important role in neuronal [...]
    
 
 0.412
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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