STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
becn1Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] (447 aa)    
Predicted Functional Partners:
uvrag
UV radiation resistance-associated gene.
   
 0.999
ATG14
Zgc:113944.
    
 0.999
bcl2l1
Bcl-XL-like protein 1.
    
 0.999
nrbf2b
Nuclear receptor-binding factor 2b.
   
 0.999
pik3r4
Phosphoinositide-3-kinase, regulatory subunit 4.
    
 0.999
pik3c3
Phosphatidylinositol 3-kinase catalytic subunit type 3.
    
 0.999
bcl2a
B-cell leukemia/lymphoma 2.
    
 0.999
ambra1a
Activating molecule in beclin-1-regulated autophagy.
   
 0.998
atg5
Autophagy protein 5; Involved in autophagic vesicle formation.
   
 
 0.998
ulk1b
Unc-51-like autophagy-activating kinase 1.
    
 0.996
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.