STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dph12-(3-amino-3-carboxypropyl)histidine synthase subunit 1; May be required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). Belongs to the DPH1/DPH2 family. DPH1 subfamily. (400 aa)    
Predicted Functional Partners:
dph3
Diphthamide biosynthesis 3.
   
 0.999
dph5
Diphthamide biosynthesis 5.
   
 0.997
dph2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).
   
0.995
dph7
Diphthamide biosynthesis 7.
      
 0.982
eef2l2
Eukaryotic translation elongation factor 2,-like 2.
    
 0.938
eef2a.2
Eukaryotic translation elongation factor 2a, tandem duplicate 2.
    
 0.938
eef2a.1
Eukaryotic translation elongation factor 2a, tandem duplicate 1.
    
 0.935
dph6
Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (By similarity). Belongs to the Diphthine--ammonia ligase family.
   
  
 0.922
eef2b
Eukaryotic translation elongation factor 2, like.
   
 
 0.886
mrm3a
rRNA methyltransferase 3A, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1485 (Gm1485) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
   
  
 0.832
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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