node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
flr | ift172 | ENSDARP00000055421 | ENSDARP00000061333 | Tetratricopeptide repeat protein 30A; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation. | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. | 0.998 |
flr | ift46 | ENSDARP00000055421 | ENSDARP00000083038 | Tetratricopeptide repeat protein 30A; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation. | Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Plays a role in early embryonic development; Belongs to the IFT46 family. | 0.999 |
flr | ift52 | ENSDARP00000055421 | ENSDARP00000066190 | Tetratricopeptide repeat protein 30A; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation. | Intraflagellar transport 52 homolog (Chlamydomonas). | 0.999 |
flr | ift57 | ENSDARP00000055421 | ENSDARP00000013774 | Tetratricopeptide repeat protein 30A; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation. | Intraflagellar transport protein 57 homolog; Required for the formation of cilia. Essential for differentiation and survival of sensory neurons. May also have pro- apoptotic function. | 0.997 |
flr | ift74 | ENSDARP00000055421 | ENSDARP00000027867 | Tetratricopeptide repeat protein 30A; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation. | Intraflagellar transport 74. | 0.998 |
flr | ift80 | ENSDARP00000055421 | ENSDARP00000116409 | Tetratricopeptide repeat protein 30A; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation. | Intraflagellar transport 80 homolog (Chlamydomonas). | 0.998 |
flr | ift81 | ENSDARP00000055421 | ENSDARP00000015953 | Tetratricopeptide repeat protein 30A; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation. | Intraflagellar transport 81 homolog. | 0.999 |
flr | ift88 | ENSDARP00000055421 | ENSDARP00000034047 | Tetratricopeptide repeat protein 30A; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation. | Intraflagellar transport 88 homolog. | 0.999 |
flr | traf3ip1 | ENSDARP00000055421 | ENSDARP00000002437 | Tetratricopeptide repeat protein 30A; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation. | TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1 and recruits TRAF3 and DISC1 to the microtubules. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity). | 0.997 |
flr | ttc26 | ENSDARP00000055421 | ENSDARP00000032176 | Tetratricopeptide repeat protein 30A; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation. | Intraflagellar transport protein 56; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Essential for maintaining proper microtubule organization within the ciliary axoneme (By similarity). Belongs to the IFT56 family. | 0.998 |
ift172 | flr | ENSDARP00000061333 | ENSDARP00000055421 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. | Tetratricopeptide repeat protein 30A; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation. | 0.998 |
ift172 | ift46 | ENSDARP00000061333 | ENSDARP00000083038 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. | Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Plays a role in early embryonic development; Belongs to the IFT46 family. | 0.997 |
ift172 | ift52 | ENSDARP00000061333 | ENSDARP00000066190 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. | Intraflagellar transport 52 homolog (Chlamydomonas). | 0.999 |
ift172 | ift57 | ENSDARP00000061333 | ENSDARP00000013774 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. | Intraflagellar transport protein 57 homolog; Required for the formation of cilia. Essential for differentiation and survival of sensory neurons. May also have pro- apoptotic function. | 0.999 |
ift172 | ift74 | ENSDARP00000061333 | ENSDARP00000027867 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. | Intraflagellar transport 74. | 0.987 |
ift172 | ift80 | ENSDARP00000061333 | ENSDARP00000116409 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. | Intraflagellar transport 80 homolog (Chlamydomonas). | 0.998 |
ift172 | ift81 | ENSDARP00000061333 | ENSDARP00000015953 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. | Intraflagellar transport 81 homolog. | 0.999 |
ift172 | ift88 | ENSDARP00000061333 | ENSDARP00000034047 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. | Intraflagellar transport 88 homolog. | 0.999 |
ift172 | traf3ip1 | ENSDARP00000061333 | ENSDARP00000002437 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. | TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1 and recruits TRAF3 and DISC1 to the microtubules. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity). | 0.998 |
ift172 | ttc26 | ENSDARP00000061333 | ENSDARP00000032176 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. | Intraflagellar transport protein 56; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Essential for maintaining proper microtubule organization within the ciliary axoneme (By similarity). Belongs to the IFT56 family. | 0.992 |