STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
egr4Early growth response 4. (352 aa)    
Predicted Functional Partners:
junbb
JunB proto-oncogene, AP-1 transcription factor subunit b.
   
 
 0.724
fosaa
V-fos FBJ murine osteosarcoma viral oncogene homolog Aa.
    
 
 0.704
npas4a
Neuronal PAS domain-containing protein 4A; Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late- response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal act [...]
   
  
 0.704
ftr50
FinTRIM family, member 50.
   
 
 0.672
ftr46
FinTRIM family, member 50.
   
 
 0.672
LOC100330744
FinTRIM family, member 50.
   
 
 0.672
ier2b
Immediate early response 2b.
   
 
 0.663
fosl2
FOS-like 2, AP-1 transcription factor subunit.
   
 
 0.661
soga3b
SOGA family member 3b.
      
 0.660
nlrp16
NACHT, LRR and PYD domains-containing protein 16.
    
 
 0.659
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.