STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spoplbSpeckle-type POZ protein-like B; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency; Belongs to the Tdpoz family. (392 aa)    
Predicted Functional Partners:
cul3a
Cullin 3a; Belongs to the cullin family.
   
 0.991
cul3b
Cullin 3b; Belongs to the cullin family.
   
 0.991
sufu
Suppressor of fused homolog.
   
 
 0.941
spop
Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. Belongs to the Tdpoz family.
  
 
 
0.906
spopla
Speckle-type POZ protein-like A; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency; Belongs to the Tdpoz family.
  
 
 
0.902
gli3
GLI family zinc finger 3.
   
 0.854
gli2a
GLI family zinc finger 2a.
   
 0.847
gli1
GLI family zinc finger 1.
   
 0.839
gli2b
GLI family zinc finger 2b.
   
 0.825
kctd2
Potassium channel tetramerization domain-containing 2.
    
 0.814
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.