STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM186Transmembrane protein 186 (228 aa)    
Predicted Functional Partners:
armc4
Armadillo repeat containing 4
      
 0.817
iqce
IQ motif containing E
      
 0.817
nt5c3a
Cytosolic 5'-nucleotidase 3; Can act both as nucleotidase and as phosphotransferase
      
 0.729
gchfr
GTP cyclohydrolase 1 feedback regulatory protein; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1
      
 0.702
bhmt
Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity)
      
 0.695
phyhipla
phytanoyl-CoA 2-hydroxylase interacting protein-like a
      
 0.670
phyhiplb
Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system
      
 0.670
AADAT
Aminoadipate aminotransferase
      
 0.658
ecsit
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa- B
    
   0.646
arhgap20
Rho GTPase activating protein 20
   
    0.584
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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