STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
usp12aUbiquitin carboxyl-terminal hydrolase 12A; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity. (371 aa)    
Predicted Functional Partners:
wdr48b
WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes.
   
 
 0.966
ENSDARP00000157149
WD_REPEATS_REGION domain-containing protein.
   
 0.932
wdr20a
WD repeat domain 20a.
   
 0.930
fancd2
FA complementation group D2.
    
 
 0.802
usp28
Ubiquitin-specific peptidase 28; Belongs to the peptidase C19 family.
   
  
 0.715
otub1b
Ubiquitin thioesterase.
      
 0.680
wdr48a
WD repeat domain 48a.
   
 
 0.678
DMWD
Zmp:0000000529.
   
 
 0.665
uchl3
Ubiquitin carboxyl-terminal hydrolase.
   
  
 0.655
wdr20b
WD repeat domain 20b.
   
 
 0.652
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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