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c21orf59 protein (Danio rerio) - STRING interaction network
"c21orf59" - UPF0769 protein C21orf59 homolog in Danio rerio
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
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c21orf59UPF0769 protein C21orf59 homolog; Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity; Belongs to the UPF0769 family (290 aa)    
Predicted Functional Partners:
ccdc65
Coiled-coil domain-containing protein 65; May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex (492 aa)
     
   
  0.946
spag1a
Sperm-associated antigen 1A; May play a role in the cytoplasmic assembly and/or trafficking of the axonemal dynein arms (427 aa)
     
   
  0.946
acot11a
acyl-CoA thioesterase 11a (579 aa)
           
  0.941
ccdc103
Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family (247 aa)
     
   
  0.861
zmynd10
Zinc finger MYND domain-containing protein 10; Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins (By similarity); Belongs to the ZMYND10 family (448 aa)
           
  0.855
lrrc6
Protein tilB homolog; Plays a crucial role in regulating cilia motility in pronephric tubules, cloaca and neural tube. Required for establishing left-right asymmetry of the body plan; controls cell fate and convergent extension (CE) movements during gastrulation, respectively, via the Wnt and the planar cell polarity (PCP) signaling pathways. Required for the proper development of renal glomeruli and tubules; Belongs to the tilB family (440 aa)
     
   
  0.850
dyx1c1
Dynein axonemal assembly factor 4; Dyslexia susceptibility 1 candidate 1 (420 aa)
     
   
  0.848
dnaaf2
Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment (566 aa)
     
   
  0.835
ENSDARG00000088132
HEAT repeat containing 2 (257 aa)
           
  0.795
ENSDARG00000078148
Dynein axonemal assembly factor 5; HEAT repeat containing 2 (280 aa)
           
  0.795
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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