node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ercc2 | ercc3 | ENSDARP00000114026 | ENSDARP00000010637 | Excision repair cross-complementation group 2. | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] | 0.999 |
ercc2 | gtf2e1 | ENSDARP00000114026 | ENSDARP00000001151 | Excision repair cross-complementation group 2. | General transcription factor IIE, polypeptide 1, alpha. | 0.996 |
ercc2 | gtf2e2 | ENSDARP00000114026 | ENSDARP00000020885 | Excision repair cross-complementation group 2. | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. | 0.997 |
ercc2 | gtf2h1 | ENSDARP00000114026 | ENSDARP00000038901 | Excision repair cross-complementation group 2. | General transcription factor IIH, polypeptide 1. | 0.999 |
ercc2 | gtf2h2 | ENSDARP00000114026 | ENSDARP00000018901 | Excision repair cross-complementation group 2. | General transcription factor IIH subunit. | 0.999 |
ercc2 | gtf2h3 | ENSDARP00000114026 | ENSDARP00000088015 | Excision repair cross-complementation group 2. | General transcription factor IIH, polypeptide 3. | 0.999 |
ercc2 | gtf2h4 | ENSDARP00000114026 | ENSDARP00000052358 | Excision repair cross-complementation group 2. | General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. | 0.994 |
ercc2 | gtf2h5 | ENSDARP00000114026 | ENSDARP00000126549 | Excision repair cross-complementation group 2. | General transcription factor IIH, polypeptide 5. | 0.998 |
ercc2 | mnat1 | ENSDARP00000114026 | ENSDARP00000027502 | Excision repair cross-complementation group 2. | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. | 0.998 |
ercc2 | xpa | ENSDARP00000114026 | ENSDARP00000055565 | Excision repair cross-complementation group 2. | Xeroderma pigmentosum, complementation group A. | 0.996 |
ercc3 | ercc2 | ENSDARP00000010637 | ENSDARP00000114026 | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] | Excision repair cross-complementation group 2. | 0.999 |
ercc3 | gtf2e1 | ENSDARP00000010637 | ENSDARP00000001151 | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] | General transcription factor IIE, polypeptide 1, alpha. | 0.997 |
ercc3 | gtf2e2 | ENSDARP00000010637 | ENSDARP00000020885 | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. | 0.997 |
ercc3 | gtf2h1 | ENSDARP00000010637 | ENSDARP00000038901 | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] | General transcription factor IIH, polypeptide 1. | 0.999 |
ercc3 | gtf2h2 | ENSDARP00000010637 | ENSDARP00000018901 | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] | General transcription factor IIH subunit. | 0.999 |
ercc3 | gtf2h3 | ENSDARP00000010637 | ENSDARP00000088015 | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] | General transcription factor IIH, polypeptide 3. | 0.999 |
ercc3 | gtf2h4 | ENSDARP00000010637 | ENSDARP00000052358 | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] | General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. | 0.998 |
ercc3 | gtf2h5 | ENSDARP00000010637 | ENSDARP00000126549 | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] | General transcription factor IIH, polypeptide 5. | 0.999 |
ercc3 | mnat1 | ENSDARP00000010637 | ENSDARP00000027502 | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. | 0.998 |
ercc3 | xpa | ENSDARP00000010637 | ENSDARP00000055565 | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] | Xeroderma pigmentosum, complementation group A. | 0.994 |